
- Episode 1 Episode 1 Guest co-host Fred Willard; actress Jennifer Beals; boxer Randy Couture; Jonny Lang performs.
- Episode 2 Episode 2 Guest co-host Fred Willard; TV personality Keshia Knight Pulliam ("Celebrity Mole Yucatan"); comic Tony Camin.
- Episode 3 Episode 3 Guest co-host Fred Willard; actor Hank Azaria; NASCAR driver Michael Waltrip; competitive eater Sonya Thomas.
- Episode 4 Episode 4 Guest co-host Fred Willard; journalist John Stossel; former NFL player Lawrence Taylor; Coheed and Cambria perform.
- Episode 5 Episode 5 Guest co-host Fred Willard; musician Nick Lachey; pro football player Warren Sapp; Shelby Lynne performs; Jimmy Kimmel broadcasts from a Houston family's home in anticipation of the Super Bowl.
- Episode 6 Episode 6 Guest co-host Kathie Lee Gifford; actress Leah Remini; actor Will Arnett; comic Don Barris.
- Episode 7 Episode 7 Guest co-host Kathie Lee Gifford; comic Adam Carolla ("The Man Show"); actress Susie Essman; comic Craig Robinson.
- Episode 8 Episode 8 Guest co-host Kathie Lee Gifford; singer Kylie Minogue; actor Adam Rodriguez; the Black Eyed Peas perform.
- Episode 9 Episode 9 Guest co-host Kathie Lee Gifford; former pro basketball player Magic Johnson; singer Missy Elliott; Buddy Guy performs.
- Episode 10 Episode 10 Guest co-host Kathie Lee Gifford; TV host Pat O'Brien; Kenny Chesney performs.
- Episode 11 Episode 11 Guest co-host Warren Sapp; comic Jim Florentine; Olympic softball pitcher Jennie Finch; the Fab Four perform.
- Episode 12 Episode 12 Guest co-host Warren Sapp; actor Dean Cain; the Bug Brothers Tim and Derek Majewski; Dizzee Rascal performs.
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Episode 179
Episode 179
Actor Billy Bob Thornton; actor Dominic Monaghan; pitcher Pedro Martinez's lucky charm, Nelson de la Rosa.
- Episode 180 Episode 180 Model Brooke Burke; Tears for Fears performs.
- Episode 181 Episode 181 Actor/comic Patton Oswalt; Bowling for Soup performs.
- Episode 186 Episode 186 Actor Blair Underwood; actress Virginia Madsen; Interpol performs.
- Episode 191 Episode 191 Actor Adam Brody; TV personality Ben Stein.
- Episode 208 Episode 208 Actor Robin Williams; Guerilla Black performs.