- Episode 1 George Packer TONIGHT: Author of The Assassins' Gate : America in Iraq, George Packer!
- Episode 2 Pierce Brosnan TONIGHT: Actor, Pierce Brosnan! Also, Jason Jones with "Spear Pressure."
- Episode 3 James Risen TONIGHT: NY Times reporter and author of State of War, James Risen!
- Episode 4 Albert Brooks TONIGHT: Star of Finding Comedy in the Muslim World, actor and filmmaker, Albert Brooks!
- Episode 5 Peter Bergen TONIGHT: CNN's terrorism analyst, Peter Bergen!
- Episode 6 Edward Lazarus TONIGHT: Author of Closed Chambers: The Rise, Fall, and Future of the Modern Supreme Court, Edward Lazarus!
- Episode 7 Eugene Jarecki TONIGHT: Documentary film maker, Eugene Jarecki! Also, Rob Corddry with "This Week in God."
- Episode 8 L. Paul Bremer TONIGHT: Author of My Year in Iraq: The Struggle to Build a Future of Hope and former Head of Coalition Provisional Authority in Iraq, L. Paul Bremer!
- Episode 9 James Woolsey TONIGHT: Former CIA Director, James Woolsey!
- Episode 10 Josh Lucas TONIGHT: Actor and star of Glory Road, Josh Lucas! Also, Nate Corddry with an American Resolution.
- Episode 11 Fred Barnes TONIGHT: Author of Rebel-in-Chief: How George W. Bush Is Redefining the Conservative Movement and Transforming America, Fred Barnes!
- Episode 12 Reza Aslan TONIGHT: Author of No god but God: The Origins, Evolution, and Future of Islam, Reza Aslan!
- Episode 13 Anthony Hopkins TONIGHT: Actor and star of The World's Fastest Indian, Anthony Hopkins! Plus "New Year's Resolution" with Ed Helms!
- Episode 14 Bernard-Henri Levy TONIGHT: Author of American Vertigo: Traveling America in the Footsteps of Tocqueville, Bernard-Henri Levy!
- Episode 15 Randy Jackson TONIGHT: Judge on American Idol, Randy Jackson!
- Episode 16 Charles Barkley TONIGHT: Retired NBA Star, Charles Barkley!
- Episode 17 Michael Beschloss TONIGHT: Author and historian, Michael Beschloss!
- Episode 18 Robert O’Harrow, Jr. TONIGHT: Author of No Place to Hide: Behind the Scenes of Our Emerging Surveillance Society, Robert O'Harrow, Jr.! Plus, "New Year's Resolution" with Dan Bakkedahl!
- Episode 19 Torie Clarke TONIGHT: Former Assistant Defense Secretary for Public Affairs, Torie Clarke! Plus, Rob Corddry with "This Week In God!"
- Episode 20 Harrison Ford TONIGHT: Actor and star of Firewall, Harrison Ford! Also, the first installment of "Klassic Kolbert."
- Episode 21 Will Arnett TONIGHT: Actor and star of Arrested Development, Will Arnett!
- Episode 22 Mike Mullane TONIGHT: Astronaut, Mike Mullane!
- Episode 23 Peter Tertzakian TONIGHT: Author of A Thousand Barrels a Second: The Coming Oil Break Point and the Challenges Facing an Energy Dependent World, Peter Tertzakian!
- Episode 24 Julianne Moore TONIGHT: Actress and star of Freedomland, Julianne Moore! Plus, "Trendspotting" with Demetri Martin.
- Episode 25 Ed Harris TONIGHT: Actor and star of Winter Passing, Ed Harris! Plus, Lewis Black with "Back in Black."
- Episode 26 Sarah Vowell TONIGHT: Author of Assassination Vacation, Sarah Vowell! Also, Nate and Rob Corddry with "Brother vs. Brother."
- Episode 27 Matthew Fox TONIGHT: Actor and star of Lost, Matthew Fox!
- Episode 28 Roger Ebert TONIGHT: Movie critic, Roger Ebert! Also, Lewis Black with "Back in Black."
- Episode 29 Eugene Linden TONIGHT: The author of The Winds of Change: Climate, Weather, and the Destruction of Civilizations, Eugene Linden!
- Episode 30 Neil Young TONIGHT: Musician and composer, Neil Young!
- Episode 31 Bruce Bartlett TONIGHT: The author of Impostor: How George W. Bush Bankrupted America and Betrayed the Reagan Legacy, Bruce Bartlett!
- Episode 32 Eric Burns TONIGHT: The author of Infamous Scribblers: The Founding Fathers and the Rowdy Beginnings of American Journalism, Eric Burns!
- Episode 33 Bart Ehrman TONIGHT: The author of Misquoting Jesus: The Story Behind Who Changed the Bible and Why, Bart Ehrman! Plus "This Week in God" with Rob Corddry.
- Episode 34 Natalie Portman TONIGHT: Actress and star of V for Vendetta, Natalie Portman!
- Episode 35 Vin Diesel TONIGHT: Actor and star of Find Me Guilty, Vin Diesel!
- Episode 36 Clive Owen TONIGHT: Actor and star of Inside Man, Clive Owen!
- Episode 37 General Georges Sada TONIGHT: Author of Saddam's Secrets: How an Iraqi General Defied And Survived Saddam Hussein, General Georges Sada! Also, "Trendspotting" with Demetri Martin!
- Episode 38 Senator Russ Feingold TONIGHT: Wisconsin Senator, Russ Feingold!
- Episode 39 Michael Mandelbaum TONIGHT: Author of The Case For Goliath: How America Acts As The World's Government in the Twenty-first Century, Michael Mandelbaum
- Episode 40 Michael Gordon TONIGHT: Author of Cobra II : The Inside Story of the Invasion and Occupation of Iraq, Michael Gordon!
- Episode 41 Fareed Zakaria TONIGHT: Newsweek International editor, Fareed Zakaria!
- Episode 42 Queen Latifah TONIGHT: Actress and star of Ice Age: The Meltdown, Queen Latifah!
- Episode 43 Sharon Stone TONIGHT: Actress and star of Basic Instinct 2, Sharon Stone!
- Episode 44 Ricky Gervais TONIGHT: Actor and podcast host of "The Ricky Gervais Show", Ricky Gervais! Also, Ed Helms with "This Week In God".
- Episode 45 Studs Terkel TONIGHT: Broadcaster and author of "And They All Sang: Adventures of an Eclectic Disc Jockey", Studs Terkel! Also, Senator John McCain stops by to defend his decision to talk in…
- Episode 46 Gen. Tony Zinni TONIGHT: Retired Marine General and author of "The Battle for Peace: A Frontline Vision of America's Power and Purpose", Gen. Tony Zinni!
- Episode 47 Josh Hartnett TONIGHT: Actor and star of Lucky Number Slevin, Josh Hartnett! Also, Dan Bakkedahl learns about "Beach Ploys".
- Episode 48 Jon Meacham TONIGHT: The author of American Gospel: God, the Founding Fathers, and the Making of a Nation, Jon Meacham! Also, Ed Helms travels to Alaska to find out about the enormous…
- Episode 49 Ryan Nerz TONIGHT: The author of Eat This Book: A Year of Gorging and Glory on the Competitive Eating Circuit, Ryan Nerz!
- Episode 50 Dennis Quaid TONIGHT: Actor and star of American Dreamz, Dennis Quaid!
- Episode 51 Sen. Ted Kennedy TONIGHT: Senator from Massachusetts, Sen. Ted Kennedy! Also, Jason Jones with Not In Your Front Yard.
- Episode 52 Efraim Halevy TONIGHT: The author of Man in the Shadows: Inside the Middle East Crisis with a Man Who Led the Mossad, Efraim Halevy!
- Episode 53 Tom Selleck TONIGHT: The author of Man in the Shadows: Inside the Middle East Crisis with a Man Who Led the Mossad, Efraim Halevy!
- Episode 54 Kimberley Strassel TONIGHT: Wall Street Journal editor, Kimberley Strassel!
- Episode 55 Robin Williams TONIGHT: Actor and star of R.V., Robin Williams!
- Episode 56 Matthew Continetti TONIGHT: The author of The K Street Gang: The Rise and Fall of the Republican Machine, Matthew Continetti!
- Episode 57 Madeleine Albright TONIGHT: The author of The Mighty and the Almighty: Reflections on America, God, and World Affairs, Madeleine Albright!
- Episode 58 Clark Kent Ervin TONIGHT: The author of Open Target: Where America Is Vulnerable To Attack, Clark Kent Ervin!
- Episode 59 John Malkovich TONIGHT: Actor John Malkovich!
- Episode 60 David Remnick TONIGHT: The author of Reporting: Writings from the New Yorker, David Remnick!
- Episode 61 Eric Shawn TONIGHT: Author of The U.N. Exposed: How the United Nations Sabotages America's Security and Fails the World, Eric Shawn!
- Episode 62 Billy Connolly TONIGHT: Stand-up comedian Billy Connolly!
- Episode 63 Francis Fukuyama TONIGHT: Author of America at the Crossroads: Democracy, Power, and the Neoconservative Legacy, Francis Fukuyama!
- Episode 64 Howard Dean TONIGHT: The Chairman of the Democratic National Committee, Howard Dean!
- Episode 65 Denis Leary TONIGHT: Actor and star of Rescue Me, Denis Leary!
- Episode 66 Ramesh Ponnuru TONIGHT: A senior editor for National Review, Ramesh Ponnuru! Plus, Lewis Black: Back in Black.
- Episode 67 Willie Nelson TONIGHT: Legendary country musician and performer of You Don't Know Me: The Songs of Cindy Walker, Willie Nelson!
- Episode 68 Caroline Kennedy TONIGHT: Caroline Kennedy, founder of the Profiles In Courage Award.
- Episode 69 Bill Bennett TONIGHT: Former Secretary of Education and author of America, Bill Bennett.
- Episode 70 Bonnie Hunt TONIGHT: Actress Bonnie Hunt from the movie Cars. Plus, Lewis Black reports in Back in Black!
- Episode 71 Lily Tomlin TONIGHT: Legendary comedian Lily Tomlin!
- Episode 72 Thomas Friedman TONIGHT: The author of The World Is Flat: A Brief History of the Twenty-first Century, Thomas L. Friedman!
- Episode 73 Ken Mehlman TONIGHT: The chair of the Republican National Committee, Ken Mehlman!
- Episode 74 Tim Russert TONIGHT: The Host of NBC's Meet the Press and the author of Wisdom of Our Fathers: Lessons and Letters from Daughters and Sons, Tim Russert!
- Episode 75 Louis C.K. TONIGHT: The star of the new series Lucky Louie, Louis C.K.!
- Episode 76 Calvin Trillin TONIGHT: American journalist, humorist, and author of Messages from My Father!, Calvin Trillin!
- Episode 77 Juliet Eilperin Tonight: Washington Post reporter Juliet Eilperin, author of Fight Club Politics: How Partisanship is Poisoning the House of Representatives.
- Episode 78 Anderson Cooper TONIGHT: Host of CNN's Anderson Cooper: 360, Anderson Cooper.
- Episode 79 Adam Sandler
- Episode 80 Lance Armstrong
- Episode 81 Helen Thomas
- Episode 82 Al Gore
- Episode 83 Kevin Spacey
- Episode 84 Illario Pantano Tonight former U.S. Marine and co-author of Warlord: No Better Friend, No Worse Enemy, Illario Pantano.
- Episode 85 John Dean Tonight: Former Nixon legal counsel and author of Conservatives Without Conscience, John Dean.
- Episode 86 Shawn Wayans
- Episode 87 Owen Wilson Tonight: Actor and one of the stars of You, Me and Dupree, Owen Wilson.
- Episode 88 Gordon Chang Tonight: Gordon Chang, author of Nuclear Showdown: North Korea Takes On The World.
- Episode 89 M. Night Shyamalan Tonight: Director of the movie Lady in the Water, M. Night Shaymalan.
- Episode 90 James Maguire Tonight: The author of American Bee: The National Spelling Bee and the Culture of Word Nerds, James Maguire.
- Episode 91 Paul Giamatti Tonight: Actor and star of the movie Lady in the Water, Paul Giamatti.
- Episode 92 Senator John McCain
- Episode 93 Ed Burns TONIGHT: actor, writer and director of The Groomsman, Ed Burns.
- Episode 94 Sharon Weinberger TONIGHT: Defense reporter and author of Imaginary Weapons: A Journey Through the Pentagon's Scientific Underworld, Sharon Weinberger. Also, Lewis Black in "Back in Black.
- Episode 95 Dr. Alon Ben-Meir TONIGHT: NYU Professor, Dr. Alon Ben-Meir.
- Episode 96 Will Ferrell
- Episode 97 Vali Nasr TONIGHT: Professor of Middle East and South Asia politics and author of The Shia Revival: How Conflicts within Islam Will Shape the Future, Vali Nasr.
- Episode 98 Chris Paine TONIGHT: Writer and director of the documentary Who Killed The Electric Car?, Chris Paine.
- Episode 99 Danny DeVito TONIGHT: Actor and star of It's Always Sunny In Philadelphia, Danny DeVito.
- Episode 100 Brian Williams
- Episode 101 Craig Glenday
- Episode 102 Dale Earnhardt Jr. TONIGHT: Famous NASCAR driver Dale Earnhardt Jr.
- Episode 103 Thomas E. Ricks TONIGHT: The author of Fiasco: The American Military Adventure in Iraq, Thomas E. Ricks.
- Episode 104 Samuel L. Jackson TONIGHT: The star of the movie Snakes on a Plane, Samuel L. Jackson.
- Episode 105 Thomas Kean
- Episode 106 Matt Dillon
- Episode 107 Reza Aslan Tonight, author and scholar of comparative religions, Reza Aslan.
- Episode 108 William Cohen Tonight former Secretary of Defense William Cohen, author of Dragon Fire.
- Episode 109 Frederick Lane Tonight Frederick Lane, author of The Decency Wars: The Campaign to Cleanse American Culture.
- Episode 110 Martin Short Tonight actor and comedian Martin Short.
- Episode 111 Maggie Gyllenhaal Tonight actress and star of sherrybaby, Maggie Gyllenhaal.
- Episode 112 Gary Hart Tonight former U.S.
- Episode 113 Ed Gillespie Tonight political advisor and author of Winning Right: Campaign Politics and Conservative Policies, Ed Gillespie.
- Episode 114 Norm MacDonald Tonight comedian Norm MacDonald.
- Episode 115 Bill Clinton
- Episode 116 Ben Affleck Tonight actor and star of Hollywoodland Ben Affleck.
- Episode 117 Johnny Knoxville Tonight actor and star of Jackass Number Two, Johnny Knoxville.
- Episode 118 CC Goldwater Tonight founder of Sweet Pea Films and producer of the documentary Mr. Conservative: Goldwater On Goldwater, CC Goldwater.
- Episode 119 Pat Buchanan Tonight conservative pundit Pat Buchanan.
- Episode 120 Pervez Musharraf
- Episode 121 Al Franken Tonight comedian Al Franken.
- Episode 122 Jim McGreevey Tonight, former Governor of New Jersey and author of The Confession, Jim McGreevey.
- Episode 123 Trent Lott Tonight Mississippi Senator Trent Lott, author of Herding Cats: A Life in Politics.
- Episode 124 Dennis Miller Tonight comedian Dennis Miller.
- Episode 125 Ian Bremmer Tonight the President of the Eurasia Group and author of The J Curve: A New Way To Understand Why Nations Rise And Fall, Ian Bremmer.
- Episode 126 David Rakoff
- Episode 127 James Baker Tonight former Secretary of State and author of Work Hard, Study...
- Episode 128 David Cross Tonight comedian and star of Freak Show, David Cross.
- Episode 129 Lou Dobbs Tonight the host of CNN's Lou Dobbs Tonight, Lou Dobbs.
- Episode 130 David Mark Tonight David Mark, author of Going Dirty: The Art of Negative Campaigning.
- Episode 131 Frank Rich Tonight New York Times columnist Frank Rich, author of The Greatest Story Ever Sold: The Decline and Fall of Truth from 9/11 to Katrina.
- Episode 132 Amy Sedaris Tonight actress Amy Sedaris, author of I Like You: Hospitality Under the Influence.
- Episode 133 John Ashcroft Tonight fromer U.S. Attorney General John Ashcroft.
- Episode 134 Kirsten Dunst
- Episode 135 LeBron James Tonight NBA superstar LeBron James.
- Episode 136 John Meuller Tonight Ohio State policy analyst and author of Overblown: How Politicians and the Terrorism Industry Inflate National Securty Threats and Why We Believe Them, John Meuller.
- Episode 137 Midwest Midterm Midtacular Tonight John Oliver talks to people who were wooed in 2004. Also Demitri Martin reports on the clubs at Ohio State.
- Episode 138 Sacha Baron Cohen Tonight comedian and star of Borat, Sacha Baron Cohen.
- Episode 139 Jerry Seinfeld
- Episode 140 Indesion 2006 Election Night Combined with The Colbert Report, Dan Rather stops by.
- Episode 141 Howard Dean Tonight chairman of the Democratic National Committe, Howard Dean.
- Episode 142 Dustin Hoffman Tonight actor and co-star of Stranger Than Fiction, Dustin Hoffman.
- Episode 143 Tina Fey Tonight writer, actress and star of 30 Rock, Tina Fey.
- Episode 144 John Edwards Tonight former Senator from North Carolina and author of Home: Blueprints of Our Lives, John Edwards.
- Episode 145 Ted Koppel Tonight former anchor of Nightline, Ted Koppel.
- Episode 146 Muhammad Yumus Tonight professor of economics and founder of the Grameen Bank, Muhammad Yumus.
- Episode 147 Rahm Emanuel TONIGHT: Rep. Rahm Emanuel, D, Rep-ILL, chair of the Congressional Campaign Committee for 2006 elections.
- Episode 148 Tom Waits Tonight's Guest: Musician Tom Waits.
- Episode 149 George Clooney
- Episode 150 Tenacious D Tonight's guests: Jack Black and Kyle Gass, collectively known as Tenacious D.Black and Gass star in the new film Tenacious D: The Pick of Destiny.
- Episode 151 Nathan Lane Tonight actor and Broadway star Nathan Lane.
- Episode 152 Sen. John Danforth
- Episode 153 Eve Herold Tonight the director of public policy research at the Genetics Policy Institute and author of Stem Cell War: Inside Stories from the Frontlines, Eve Herold.
- Episode 154 Ed Viesturs Tonight mountain climber and author of No Shortcut to the Top: Climbing the World's 14 Hightest Peaks, Ed Viesturs.
- Episode 155 Sen. Lincoln Chafee
- Episode 156 Fareed Zakaria Tonight the editor for Newsweek International, Fareed Zakaria.
- Episode 157 Ricky Gervais Tonight actor and star of Extras, Ricky Gervais.
- Episode 158 Rajiv Chandraeskaran Tonight the assistant managing editor for the Washington Post and author of Imperial Life in the Emerald City: Inside Iraq’s Green Zone, Rajiv Chandraeskaran.
- Episode 159 Gov. Tom Vilsack Tonight Iowa Governor and 2008 Presidential candidate, Tom Vilsack.
- Episode 160 Bill Kristol
- Episode 161 Ben Stiller Tonight actor and star of Night at the Museum, Ben Stiller.