
- Episode 1 Aaron Brown / Ralph Geidel / Paolo Nutini
- Episode 2 Michael Rapaport / Joely Fisher
- Episode 3 Virginia Madsen / Jason Ritter / Matt Baetz
- Episode 4 Gary Sinise / Whitley Strieber / Chris Isaak
- Episode 5 Mia Kirshner / Method Man
- Episode 6 Edward Norton / Ethan Suplee / LeToya
- Episode 7 Skeet Ulrich / Nora Ephron / Rodney Atkins
- Episode 8 James Woods / George Eads / Heartland
- Episode 9 Chazz Palminteri / Kerry Washington / French Kiss
- Episode 10 Bradley Whitford / Trudie Styler / Larry Johnson / Sam Roberts
- Episode 11 Lauren Graham / Nick Griffin / Joan Jett Craig welcomes actress Lauren Graham and musician Joan Jett. Nick Griffin performs stand-up and Tim Meadows reports from Tora Bora. Joan Jett & The Blackhearts perform "A.C.D.C".
- Episode 12 Marie Osmond / Jacinda Barrett / Mitch Albom
- Episode 13 Forest Whitaker / Julie Walters / Shang Forbes
- Episode 14 Billy Connolly / Michael Ian Black / M. Ward
- Episode 15 Billy Bob Thornton / Duane Martin / Starsailor
- Episode 16 Jon Favreau / Kristen Bell / Amos Lee
- Episode 17 Tim Daly / David Cross / Diana Krall
- Episode 18 Busta Rhymes / Connie Britton
- Episode 19 Brooke Shields / Michael Ian Black / Billy Bragg
- Episode 20 Howie Mandel / Andy Summers / Rodrigo y Gabriela
- Episode 21 Emmitt Smith / Kristin Chenoweth
- Episode 22 Laura Linney / Jordanna Brester / Say Anything
- Episode 23 David Arquette / Monica
- Episode 24 Jennifer Beals / Michael Sheen / Chingy
- Episode 25 Michael Caine / Mario Vasquez
- Episode 26 Maria Bello / Derek Luke / Robin Thicke
- Episode 27 Alan Arkin / Paul Haggis / Jimmy Pardo
- Episode 28 Ron Rifkin / Kevin Nealon / Corinne Bailey Rae
- Episode 29 Brooke Hogan / Eva La Rue / Jason Schwartzman
- Episode 30 Danny Bonaduce / Gene Pompa / Mew
- Episode 31 Kim Raver / Bob Saget / Deana Carter & Heart
- Episode 32 Carrie Fisher / Todd Oliver / Alice Cooper
- Episode 33 Barry Pepper / Amy Sedaris / Carlos Alazraqui
- Episode 34 Tim Robbins / Jamie Lidell
- Episode 35 Alec Baldwin / Barry Manilow
- Episode 36 Val Kilmer / Rebecca Gayheart / Paolo Nutini
- Episode 37 Merv Griffin / Marshall Faulk / Carrot Top
- Episode 38 Emma Thompson / Eamonn Walker / Joseph Arthur
- Episode 39 Ashley Judd / Seth MacFarlane / Pet Shop Boys
- Episode 40 Hugh Laurie / Spike Feresten / OK Go
- Episode 41 Steven Weber / Emily Deschanel / Phil Rosenthal
- Episode 42 Anne Heche / Rain Pryor / Jeff Caldwell
- Episode 43 Maura Tierney / Scott Turow / Lindsay Buckingham
- Episode 44 Ice-T / Henry Cho
- Episode 45 Christian Slater / Sue Johanson / Driveblind
- Episode 46 Emilio Estevez / Eva Pigford / Jim Short
- Episode 47 Fred Willard / Ashley Scott / Gabriel Iglesias
- Episode 48 Felicity Huffman / Dax Shepard / Akon
- Episode 49 William Shatner / Mike Luckovich / Driveblind
- Episode 50 William H. Macy / Jeri Ryan / Isabel Allende
- Episode 51 Anthony LaPaglia / Carl Edwards / Sparta
- Episode 52 John Waters / Alex Borstein / Plain White T’s
- Episode 53 Kevin Smith / Suzy Nakamura / Joseph Arthur
- Episode 54 Betty White / Twiggy / Sam Moore & Travis Tritt
- Episode 55 John Stamos / Sean Maguire / Ziggy Marley
- Episode 56 Chris Kattan / Chiwetel Ejiofor / Ciara
- Episode 57 John Novasad / Tyrese
- Episode 58 Ted Danson / Julia Sweeney / Akon
- Episode 59 Camryn Manheim / Stephen Fry
- Episode 60 Rob Morrow / Lucy Lawless / Jet
- Episode 61 Pat Croce / Jewel
- Episode 62 Michael Rapaport / Tom Kenny
- Episode 63 Edward Norton / Jenna Fisher
- Episode 64 Laura Dern / Ming Tsai / Danny Elfman
- Episode 65 Paula Poundstone / Xzibit
- Episode 66 Samuel L. Jackson / Avi Liberman / Hinder
- Episode 67 Dominic Monaghan / Anthony Mackie / Twisted Sister
- Episode 68 James Denton / Dan Gabriel / Julie Gribble
- Episode 69 Kate Walsh / Clark Gregg / Skyler Stone
- Episode 70 Carl Reiner / Tracee Ellis Ross / Max Brooks
- Episode 71 Neil Patrick Harris / Sherri Shepherd / Hellogoodbye
- Episode 72 Mario Lopez / Shawn Colvin / Ne-Yo
- Episode 73 Jonathan Silverman / Antonio Gates / Greg Proops
- Episode 74 LL Cool J / Masi Oka / Chris Daughtry
- Episode 75 Emily Watson / Ed Begley Jr. / Cash Levy
- Episode 76 Emily Blunt / Louis C.K.
- Episode 77 Paul Teutul Sr. & Paul Teutul Jr. / Kelly Hu / Greg Owen
- Episode 78 Helen Mirren / Steve Trevino
- Episode 79 Juliette Lewis / Aaron Lewis / Common
- Episode 80 Chevy Chase / Hannah Storm / Montgomery
- Episode 81 Tony Gonzalez / Fantasia
- Episode 82 Dylan McDermott / Connie Nielsen / Billy Bragg
- Episode 83 Julie Bowen / Terry Crews / Michael Meehan
- Episode 84 Chad Lowe / RZA
- Episode 85 Henry Winkler / Zoe Saldana / Jet
- Episode 86 Jerry Springer / Robert Dubac / Aaron Lewis
- Episode 87 Danny Bonaduce / Tom Lennon / Ben Garant
- Episode 88 Mena Suvari / Lawrence Block / Naked Trucker
- Episode 89 Bob Saget / Kaylee Defer / Jonny Lang
- Episode 90 Thandie Newton / The Game
- Episode 91 Eddie Griffin / Mat Kearney / Steve Mazan
- Episode 92 Peter O’Toole / Joely Fisher / Dierks Bentley & The Grascals
- Episode 93 Aisha Tyler / Harry Shearer / Tyler Williamson
- Episode 94 David Hasselhoff / Richard Wiese / K.T. Tunstall
- Episode 95 Jennifer Love Hewitt / John Cena / Three Days Grace
- Episode 96 Kiefer Sutherland / Sam Tripoli / Rich Boy
- Episode 97 Virginia Madsen / David Steinberg / Unwritten Law
- Episode 98 Patricia Heaton / Parminder Nagra
- Episode 99 Danny Bonaduce / Ioan Gruffudd / Gordie Brown
- Episode 100 Mark Ruffalo / Wolfgang Puck / Tom Lennon & Ben Garant
- Episode 101 Jennifer Tilly / Ami James / Rodney Atkins
- Episode 102 Regis Philbin / James McAvoy / Red Jumpsuit Apparatus
- Episode 103 Jill Hennessy / Oliver Hudson / Jim McDonald
- Episode 104 Billy Connolly / Tricia Helfer / Blake Shelton
- Episode 105 Jennifer Tilly / Seth MacFarlane / The Cat Empire
- Episode 106 John Mellencamp / Oscar De La Hoya
- Episode 107 Jennifer Hudson / Gerard Butler / Anberlin
- Episode 108 Poppy Montgomery / Jeremy Roenick / Paul Morrissey
- Episode 109 Andy Garcia / Rob Corddry
- Episode 110 Bill Maher / Jacinda Barrett / Razorlight
- Episode 111 Kerry Washington / Jeff Applebaum / Aaron Lewis
- Episode 112 Merv Griffin / Nia Long / John Mellencamp
- Episode 113 Cuba Gooding Jr. / Joely Richardson / Andy Vastola
- Episode 114 Tom Arnold / Drake Witham / Hinder
- Episode 115 Joss Stone / Rainn Wilson
- Episode 116 Randy Jackson / Piper Perabo / Roy Wood Jr.
- Episode 117 Sigourney Weaver / Kal Penn / The Ataris
- Episode 118 Jeff Goldblum / Papa Roach
- Episode 119 Chandra Wilson / Bobby Miyamoto / Bone Thugs N’ Harmony
- Episode 120 Josh Brolin / Jason Segel / Matt Knudsen
- Episode 121 Rose McGowan / Wolfgang Puck
- Episode 122 Robert Rodriguez / John C. McGinley
- Episode 123 Sydney Tamiia Poitier / Ice Cube / Omarion
- Episode 124 Carla Gugino / Randy Couture / Redman
- Episode 125 Kurt Russell / Barry Sonnenfeld / Paul Wall
- Episode 126 Quentin Tarantino / Laura Prepon
- Episode 127 Jeff Probst / Amy Yasbeck / Greg Warren
- Episode 128 David Duchovny / Nia Long / K-os
- Episode 129 Julia Louis-Dreyfus / Rodney Carrington / Cold War Kids
- Episode 130 Mary Hart / Brady Quinn / The Exies
- Episode 131 Paula Abdul / Vinnie Jones / Billy D. Washington
- Episode 132 Jerry Springer / Mario / Simply Red
- Episode 133 Jenny McCarthy / Frank McCourt / Mo Mandel
- Episode 134 Jon Cryer / Boyd Matson / Good Charlotte
- Episode 135 Frank Caliendo / Samantha Mathis / The Noisettes
- Episode 136 Tim Daly / Charlie Viracola / Joe
- Episode 137 Eric Bana / Julia Sweeney / Fountains of Wayne
- Episode 138 Alice Cooper / Michael Rosenbaum / Gary Gulman
- Episode 139 Molly Shannon / Duane Martin / Ozomatli
- Episode 140 Sophia Bush / Ne-Yo
- Episode 141 Floyd Mayweather / Julianne Nicholson / Lynne Koplitz
- Episode 142 Steven Wright / Carrie Ann Inaba / Dinosaur Jr.
- Episode 143 Garry Shandling / Nathan Fillion / Craig Morgan
- Episode 144 Larry the Cable Guy / Maureen McCormick / Montgomery Gentry
- Episode 145 Carrot Top / Miranda Lambert
- Episode 146 Roseanne Barr / Malachy McCourt
- Episode 147 Bob Barker / Elizabeth Banks / Modest Mouse
- Episode 148 Phil McGraw / Tori Amos
- Episode 149 Gina Gershon / Dan Naturman / The Exies
- Episode 150 Lance Burton / Matt Serra / Chantal Kreviazuk
- Episode 151 Carrie Fisher / Naomie Harris / Nathan Gibson
- Episode 152 Jason Randal / Cat Deeley / Albert Hammond Jr.
- Episode 153 Chi McBride / Rick Thomas / Patti Smith
- Episode 154 Bob Saget / Guy Torry / Jade
- Episode 155 Dennis Hopper / Eddie Pence / Darryl Worley
- Episode 156 Rosie Perez / David Milch / Patti Smith
- Episode 157 Carl Reiner / Jonah Hill / Bright Eyes
- Episode 158 Don Cheadle / Bret Michaels / Poison
- Episode 159 Jon Heder / Criss Angel
- Episode 160 Don Rickles / Ali Wentworth / Marty Stuart
- Episode 161 Parker Posey / Ian Hunter
- Episode 162 Eric Idle / S. Epatha Merkerson / Guy Torry
- Episode 163 Jeff Bridges / Carrie-Anne Moss / Mute Math
- Episode 164 Episode 164
- Episode 165 Avril Lavigne / Ioan Gruffudd
- Episode 166 Drew Pinsky / Enrique Iglesias
- Episode 167 Mo’Nique / Big and Rich
- Episode 168 Ben Kingsley / Mary McCormack / Jesse Malin
- Episode 169 Eddie Izzard / John Roy / The Goo Goo Dolls
- Episode 170 Wanda Sykes / Tim Spall / Bobby Valentino
- Episode 171 Janeane Garofalo / Tina Brown / Bob Marley
- Episode 172 Mandy Moore / David Steinberg
- Episode 173 Wayne Brady / Mary Elizabeth Winstead / Ben Kweller
- Episode 174 Chris Isaak / Cory Kahaney
- Episode 175 Dr. Kevin Fitzgerald / Sinead O’Connor
- Episode 176 Kristen Bell / Wolfgang Puck / Big and Rich
- Episode 177 Brenda Blethyn / Mike Rowe / Army of Me
- Episode 178 Amy Sedaris / Jackie Collins / Breaking Benjamin
- Episode 179 Kathy Griffin / Ken Bruen / Marty Stuart
- Episode 180 Cedric the Entertainer / Kara Cooney / Jeff Keith
- Episode 181 Julie Chen / James Marsden / Sara Bareilles
- Episode 182 Ted Danson / Maggie Q / Silverchair
- Episode 183 Rupert Grint / Dr. Dog
- Episode 184 Glenn Close / Jeffrey Ross / Lily Allen
- Episode 185 Julia Stiles / Carl Bernstein
- Episode 186 Jason Priestley / Sherri Shepherd / Chris Reid
- Episode 187 Aaron Eckhart / Hanson
- Episode 188 James Denton / Amber Stevens / The Cribs
- Episode 189 Drew Carey / Megalyn Echikunwoke
- Episode 190 Jon Voight / Alicia Coppola / Will Marfori
- Episode 191 Miss Piggy / Jonathan Silverman / Glen Hansard / Markéta Irglová
- Episode 192 Julie Delpy / Alfred Molina
- Episode 193 Pamela Anderson / Nellie McKay / Hans Klok / Avi Liberman
- Episode 194 Kyra Sedgwick / Paula Poundstone / Emerson Drive
- Episode 195 Ben Stein / Megyn Price / Rodney Laney
- Episode 196 Michelle Pfeiffer / Rachel Nichols / Kat DeLuna
- Episode 197 Cuba Gooding Jr. / Cash Levy / Grace Potter & the Nocturnals
- Episode 198 Tori Spelling / Brother Ali
- Episode 199 Jonah Hill / Natascha McElhone
- Episode 200 Aishwarya Rai / Dom Irrera / Lifehouse
- Episode 201 Masi Oka / Emily Fox / Emerson Hart
- Episode 202 Aisha Tyler / Dwayne Perkins / Augie March
- Episode 203 Tony Danza / Rose Byrne
- Episode 204 Nick Cannon / Alan Bean / Jeremy Fisher
- Episode 205 Tom Lennon / Elizabeth Perkins / Wendy Kamenoff
- Episode 206 Samuel L. Jackson / The Cliks
- Episode 207 Holly Hunter / Adam Goldberg / Ferraby Lionheart